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Diego Angeles Valdez

I am currently a Ph.D. student at the Rijksuniversiteit Groningen (UG) and the Universidad Nacional Autónoma de México (UNAM) for a double degree in Psychology, focusing on the study of neuropsychiatric disorders in humans and non-human animals. During my academic career, I obtained a Master's degree in Neurobiology and gained valuable experience at the National Laboratory of Magnetic Resonance Imaging (LANIREM), the Neuroimaging Laboratory of the National Institute of Psychiatry (INPRFM) and the University Medical Centre Groningen (UMCG). My work at these institutions consisted of data acquisition, application of MRI studies and statistical analysis to investigate the neural correlates of various psychiatric disorders. My research involves advanced high-level statistical methods, MRI analysis and machine learning techniques to identify and characterise mental disorders. Throughout my academic career I have been actively involved in several projects including the identification of biomarkers in substance use disorders, specifically cocaine use disorder in humans and alcohol models in non-human animals. I have also worked on understanding the heterogeneity of depression by exploring psychopathological networks in humans.

Research experience & Education

Education

Experience

Papers and Projects

• 2024 Diego Angeles-Valdez, M.J. van Tol, Eduardo A. Garza-Villarreal: Symptomatology of first vs recurrent episodes in Major Depressive Disorder and its relation to brain structure and function. In review
• 2024 Diego Angeles-Valdez, Rozmarijn van Kleef, M.J. van Tol, Eduardo A. Garza-Villarreal: Changes in affective and cognitive domains associated with relapse prevention in remitted recurrent depression. In review
• 2024 Diego Angeles-Valdez, Alejandra Lopez-Castro, Jalil Rasgado-Toledo, Lizbeth Naranjo-Albarran, Eduardo A. Garza-Villarreal: Improved classification of alcohol intake groups in the Intermittent-Access Two-Bottle choice rat model using a latent class linear mixed model. https://www.biorxiv.org/content/10.1101/2024.09.06.611716v1
• 2024 Rasgado-Toledo, J., Angeles-Valdez, D., Carranza-Aguilar, C.J., Lopez-Castro, A., Medina-Sánchez, D., Trujillo-Villarreal, L.A., Serrano-Ramirez, M.S., Elizarraras-Herrera, D.A., Garza-Villarreal, E.A: The effect of chronic stress and chronic alcohol consumption in behavior, brain structural and functional connectivity in a rat model. In review
• 2024 Ana Débora Elizarraras-Herrera, David Medina-Sánchez, Mariana Stefania Serrano-Ramírez, Diego Angeles-Valdez, María Antonieta Carbajo-Mata, Luis A. Trujillo Villarreal, César J. Carranza-Aguilar, Eduardo A. Garza-Villarreal: Morphine self-administration causes changes in brain volume and region-specific microglial alterations in male Wistar rats. In review
• 2024 Angeles-Valdez, D., Rasgado-Toledo, J., Villicaña, V. et al: The Mexican dataset of a repetitive transcranial magnetic stimulation clinical trial on cocaine use disorder patients: SUDMEX TMS.Published https://www.nature.com/articles/s41597-024-03242-yciteas
• 2024 Luis A. Trujillo-Villarreal, Gabriela Cruz-Carrillo, Diego Angeles-Valdez, Eduardo A. Garza-Villarreal and Alberto Camacho-Morales: Published in eNeuro https://www.eneuro.org/content/11/2/ENEURO.0194-23.2023.abstract/
• 2023 Li, J., Pepe, A., Gsaxner, C., Luijten, G., Jin, et al: MedShapeNet - A Large-Scale Dataset of 3DcMedical Shapes for Computer Vision. Preprint https://medshapenet-ikim.streamlit.app/
• 2023 Grandjean, J., Desrosiers-Gregoire, G., Anckaerts, C., Angeles-Valdez, D., Ayad, F., Barrière, D. A., ... & Houwing, D. J: A consensus protocol for functional connectivity analysis in the rat brain Published https://www.nature.com/articles/s41593-023-01286-8
• 2023 Cruz-Carrillo, G., Trujillo-Villarreal, L. A., Angeles-Valdez, D., Concha, L., Garza-Villarreal, E. A., & Camacho-Morales, A: Prenatal Cafeteria Diet Primes Anxiety-like Behavior Associated to Defects in Volume and Diffusion in the Fimbria-fornix of Mice Offspring Published https://www.sciencedirect.com/science/article/abs/pii/S0306452222006297
• 2022 Angeles-Valdez, D., Rasgado-Toledo, J., Issa-Garcia, V., Balducci, T., Villicaña, V., Valencia, A., ... & Garza-Villarreal, E. A: The Mexican magnetic resonance imaging dataset of patients with cocaine use disorder: SUDMEX CONN Published https://www.sciencedirect.com/science/article/abs/pii/S0306452222006297
• 2022 Trujillo Villarreal L.A., Cruz-Carrillo G., Angeles-Valdez, D, Devenyi G., Chakravarty M. & Garza-Villarreal E, Camacho-Morales: Transgenerational effect of maternal high caloric diet on brain macro and microstructure during anxiety phenotype in Wistar rat. Review
• 2022 Lopez-Castro, A., Angeles-Valdez, D., Rojas-Piloni, G., & Garza-Villarreal, E. A: Focal electrical stimulation on an alcohol disorder model using MRI-compatible chronic neural monopolar carbon fiber electrodes. bioRxiv. Published https://www.frontiersin.org/articles/10.3389/fnins.2022.945594/full
• 2022 Jiménez, S., Mercadillo, R.E., Angeles-Valdez, D., & Garza-Villarreal, E. A: Social closeness modulates brain dynamics during trust anticipation Published https://www.nature.com/articles/s41598-022-20827-y
• 2022 Drossel, G., Angeles-Valdez, D., Garza-Villarreal, E., & Zilverstand, A: Subtypes in Individuals With Current Cocaine Use Disorder and Their Impairments in Negative Emotionality and Executive Function Published https://www.nature.com/articles/s41598-022-20827-y
• 2022 Reyes-Ortega, P., Angeles-Valdez, D., Rodríguez, V. M., Garza-Villarreal, E. A. & Reyes-Haro, D: Cellular reorganization in the prefrontal cortex of young female rats after remission from anorexia. Review in process
• 2022 Jiménez, S., Angeles-Valdez, D., Rodríguez-Delgado, A., Fresán, A., Miranda, E., Alcalá-Lozano, R., ... & Garza-Villarreal, E. A: Machine learning detects predictors of symptom severity and impulsivity after dialectical behavior therapy skills training group in borderline personality disorder. Journal of Psychiatric Research, 151, 42-49. https://www.sciencedirect.com/science/article/abs/pii/S0022395622001923
• 2019 Jiménez, S., Angeles-Valdez, D., Villicaña, V., Reyes-Zamorano, E., Alcala-Lozano, R., Gonzalez-Olvera, J. J., & Garza-Villarreal, E. A: Identifying cognitive deficits in cocaine dependence using standard tests and machine learning. Progress in NeuroPsychopharmacology and Biological Psychiatry, 95, 109709. Published https://www.sciencedirect.com/science/article/pii/S0278584619300740?via%3Dihub
• 2019 Jiménez, S., Sip, K. E., Mercadillo, R., Angeles-Valdez, D., Munoz-Delgado, J., Sánchez-Sosa, J. J., & Garza-Villarreal, E. A: Social closeness and latent commitment impact decisions to keep promises. https://psyarxiv.com/ujrdk/
• 2018 Balducci, T., Gonzalez-Olvera, J. J., Angeles-Valdez, D., Espinoza-Luna, I., & Garza-Villarreal, E. A: Borderline personality disorder with cocaine dependence: impulsivity, emotional dysregulation and amygdala functional connectivity. Frontiers in Psychiatry, 9, 328. https://www.sciencedirect.com/science/article/pii/S0278584619300740?via%3Dihub
• 2018 Garza-Villarreal, E. A., Alcalá-Lozano, R., Balducci, T., Angeles-Valdez, D., Chakravarty, M. M., Devenyi, G. A., & Gonzalez-Olvera, J. J: Patterns of reduced cortical thickness and striatum pathological morphology in cocaine addiction. https://www.biorxiv.org/content/10.1101/306068v2

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